Status:
COMPLETED
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
Lead Sponsor:
Dokuz Eylul University
Conditions:
Microbial Substitution
Tryptophan Metabolism Alterations
Eligibility:
All Genders
18+ years
Brief Summary
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance. Changes in...
Detailed Description
The study included patients aged 18 and above undergoing lumbar disc herniation surgery. Blood samples were collected preoperatively, at 8 hours, and at 24 hours postoperatively to analyze tryptophan ...
Eligibility Criteria
Inclusion
- Patients undergoing lumbar disc herniation surgery at Dokuz Eylül University Hospital.
- Patients who have read and consented to the informed consent form for the study.
- Age 18 years or older.
- Surgery duration exceeding 2 hours.
Exclusion
- Patients are unwilling to participate in the study.
- Surgery duration less than 2 hours.
- Patients under the age of 18.
- Patients with a history of abdominal surgery.
- Patients who received antibiotic therapy for intestinal pathology within the last 3 weeks.
- Patients with known abdominal pathologies suspected to alter the microbial flora (e.g., Crohn's disease, ulcerative colitis, celiac disease).
Key Trial Info
Start Date :
January 12 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 15 2023
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT06502223
Start Date
January 12 2022
End Date
March 15 2023
Last Update
July 16 2024
Active Locations (1)
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1
Yunu Çelik
Izmir, Balçova, Turkey (Türkiye), 35100