Status:
COMPLETED
Crohn's Disease - Inflammation and Microbial Proteolytic Activity
Lead Sponsor:
McMaster University
Conditions:
Crohn's Disease of Both Small and Large Intestine
Eligibility:
All Genders
18-70 years
Brief Summary
This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile. This is clinically important as it may be p...
Detailed Description
Crohn's disease (CD), characterized by discontinuous intestinal injury and inflammation, has been associated with changes in the luminal microbiota and impaired barrier function. Previously, the inves...
Eligibility Criteria
Inclusion
- Be aged between 18 - 70 years old
- Have a confirmed diagnosis of Crohn's disease
- Have a clinical indication for standard, white light colonoscopy to assess disease activity and extent
Exclusion
- Inability to provide written informed consent
- Presence of serious life-threatening co-morbidities
- Evidence of toxic megacolon, jaundice, cirrhosis, renal dysfunction, acute GI bleeding
- History of difficult colonoscopy, strictures or extensive diverticulosis
- Antibiotics in the last month
- Probiotics in the last week
Key Trial Info
Start Date :
December 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 20 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06503081
Start Date
December 1 2019
End Date
February 20 2025
Last Update
August 22 2025
Active Locations (1)
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1
McMaster University
Hamilton, Ontario, Canada, L8N 3Z5