Status:
RECRUITING
A Study of Radspherin® in Patients with Primary Advanced Epithelial Cancer, with Peritoneal Metastasis That Are Homologous Recombination Proficient Scheduled to Undergo Neoadjuvant Chemotherapy and Interval Debulking Surgery
Lead Sponsor:
Oncoinvent AS
Conditions:
Peritoneal Carcinomatosis
Ovarian Cancer
Eligibility:
FEMALE
18+ years
Phase:
PHASE2
Brief Summary
This is a Phase 2, controlled, randomised, parallel assignment, open label, multicentre study to evaluate efficacy and safety of a single intraperitoneal injection of Radspherin® in patients with prim...
Eligibility Criteria
Inclusion
- Able and willing to provide written informed consent and to comply with the clinical study protocol (CSP).
- Female of age ≥ 18 years.
- Patients with primary advanced high-grade serous or high-grade endometrioid epithelial ovarian, fallopian tube, or primary peritoneal cancer (FIGO Stage IIIB/C or IV).
- Peritoneal and other metastases eligible for IDS to no residual tumour.
- Adverse events recovered to at least Grade 1 from the effects (excluding alopecia) of any prior medical therapy for malignancy.
- Confirmed HR proficient by Myriad MyChoice CDx testing.
- Completed 3 or 4 cycles of NACT with regress or stable disease on diagnostic imaging and assessed to be operable to R0.
- Eastern Cooperative Oncology Group (ECOG) Performance Status Score of 0 to 2 and patient fit enough to undergo IDS and further treatment according to standard of care.
- Adequate renal function:
- • Calculated creatinine clearance using the Cockcroft-Gault formula ≥ 40 ml/min or measured creatinine clearance ≥ 40 ml/min.
- Adequate hepatic function:
- Serum bilirubin \< 1.5 x upper limit of normal (ULN), and
- Aspartate transaminase and alanine transaminase ≤ 3 x ULN.
- Adequate bone marrow function:
- Absolute neutrophil count ≥ 1.0 x 10\^9/l, and
- Platelets ≥ 100 x 10\^9/l, and
- Haemoglobin ≥ 9 g/dL.
- For females of childbearing potential, a negative pregnancy test must be documented prior to enrolment.
- For females of childbearing potential agreement to use at least one of the following highly effective (failure rate \< 1%) methods of contraception during the treatment period and for at least 9 months if they receive Radspherin®, unless hysterectomy or oophorectomy is performed during IDS.
- Total abstinence (when this is in line with the preferred and usual lifestyle of the patient), periodic abstinence (e.g. calendar, ovulation, symptothermal, post ovulation methods) and withdrawal are not acceptable methods of contraception.
- Female sterilisation (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or tubal ligation at least 6 weeks before enrolment. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment.
- Use of oral (oestrogen and progesterone), injected or implanted hormonal methods of contraception or placement of an intrauterine device or intrauterine system, or other forms of hormonal contraception that have comparable efficacy (failure rate \< 1%), for example hormone vaginal ring or transdermal hormone contraception. In case of use of oral contraception women should have been stable on the same pill for a minimum of 3 months before taking study treatment.
- Note: In addition to the use of one highly effective method of contraception as listed above, a condom is required for all male partners during the treatment period and for at least 9 months after the dose of IMP, unless vasectomised at least 6 months prior to enrolment.
Exclusion
- Known somatic or germline BRCA1 or BRCA2 mutations or confirmed HR deficient.
- Suspicion of peritoneal leak, shunt, or otherwise suspected atypical target compartment pharmacokinetics, based on investigator's judgement, patient history and diagnostic images.
- Epithelial borderline tumours, ovarian clear cell carcinoma, mucinous ovarian carcinoma, malignant Brenner tumours, non-epithelial ovarian malignancies, carcinosarcoma and neuroendocrine tumours or recurrent ovarian cancer.
- Symptomatic central nervous system metastasis.
- Another primary malignancy within the past 3 years (except for non melanoma skin cancer, cutaneous melanoma stage 1, cervical cancer in situ or FIGO 2023 Stage IA1 or IA3 prior or synchronous endometrial cancer).
- Prior abdominal/pelvic radiotherapy.
- Disease progression during 3 to 4 cycles of NACT.
- Pregnant or lactating (nursing) women.
- Active infections requiring antibiotics, and/or physician monitoring, or recurrent fever \> 38.0⁰C associated with a clinical diagnosis of active infection.
- Active liver disease with positive serology for active hepatitis B, hepatitis C or known human immunodeficiency virus (HIV).
- Concurrent congestive heart failure or prior history of New York Heart Association (NYHA) class III/IV cardiac disease.
- Any condition or illness that, in the opinion of the investigator or the medical monitor, would compromise the safety of the patients or interfere with the evaluation of the safety of the investigational medicinal product.
- In the investigator's opinion not able to comply with study procedures. Any medical or psychological condition that would preclude participation in the study or compromise the ability to give informed consent.
- Administration of an investigational medicinal product within 4 weeks, or at least 5 times the half life, prior to enrolment.
- Concurrent administration of any cancer therapy other than planned study treatment within 4 weeks prior to, and up to 4 weeks after the surgery.
- Treatment with bevacizumab within 5 weeks prior to IDS.
- Known hypersensitivity to any of the excipients of the study drug.
Key Trial Info
Start Date :
June 15 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 28 2031
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT06504147
Start Date
June 15 2024
End Date
February 28 2031
Last Update
September 26 2024
Active Locations (6)
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1
Moffitt Cancer Center
Tampa, Florida, United States, 33612
2
UZ Leuven
Leuven, Belgium
3
The Norwegian Radiumhospital
Oslo, Norway
4
Clinica Universidad de Navarra
Madrid, Spain