Status:
RECRUITING
Celecoxib for ENT Pain Management
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Parotidectomy
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to find out whether pain can be managed after an operation with celecoxib instead of oxycodone. The main question it aims to answer is if use of celecoxib plus Tylen...
Detailed Description
Surgeons have a unique opportunity to reduce opioid prescriptions - and therefore potential opioid dependence, morbidity and mortality - by altering prescribing patterns in the perioperative period. T...
Eligibility Criteria
Inclusion
- Ability to understand and the willingness to sign a written informed consent document
- Willing to comply with all study procedures and be available for the duration of the study
- Ability to take oral medication
- Undergoing superficial parotidectomy
- Individuals at least 18 years of age
- Adequate organ function as indicated by standard laboratory tests: hematology (complete blood count), clinical chemistry
Exclusion
- History of NSAIDs contraindication (severe congestive heart failure, CABG within 14 days, arrhythmias, significant coronary artery disease, cardiomyopathy, severe hepatic impairment, history of peptic ulcer disease or GI bleeding, use of anticoagulation (other than prophylactic aspirin)
- History of uncontrolled hypertension, cerebrovascular accident, sulfa allergy, allergy to celecoxib
- Concurrent use of CYP2C9 potentiator/inhibitor
- Use of investigational drugs, biologics, or devices within 30 days prior to randomization.
- Individuals who are pregnant, lactating or planning on becoming pregnant during the study.
- Not suitable for study participation due to other reasons at the discretion of the investigators.
Key Trial Info
Start Date :
February 28 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT06505187
Start Date
February 28 2025
End Date
September 1 2026
Last Update
December 3 2025
Active Locations (1)
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1
University of Wisconsin
Madison, Wisconsin, United States, 53702