Status:
COMPLETED
Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Lead Sponsor:
Damascus University
Collaborating Sponsors:
University Children's Hospital
Conditions:
One-Lung Ventilation
Thoracic Surgery
Eligibility:
All Genders
4-6 years
Phase:
NA
Brief Summary
Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups. The first is an intravenous injecti...
Detailed Description
Pediatric specific anatomy and physiology includes small ventricles with low systolic mass and poor ventricular compliance . With decreased peripheral vascular resistance (SVR) . The parasympathetic n...
Eligibility Criteria
Inclusion
- children with American Society of Anesthesiologists (ASA) grade III
- FEV1/FVC values less than 80% . FEV1/FVC ratio represents the proportion of the total vital capacity that can be exhaled in the first second of forced expiration, whereas FEV1 indicates "Force Expiratory Volume in 1 second" and FVC indicates "Forced Vital Capacity".
- Qs/Qt ratio greater than 10 .
Exclusion
- renal failure.
- hepatic dysfunction.
- congenital and valvular cardiac disease.
- neurological illnesses.
- During surgery, individuals who did not achieve complete lung isolation were excluded.
- During surgery, individuals with poor oxygen saturation (SO2 \<90%) who did not react to maneuvers and anesthetic procedures to boost saturation were removed.
- During surgery, Participants who had a heart rate of less than 80 beats per minute, did not react to atropine, or required a dosage of inotropic drugs (dopamine) were also removed from the trial.
Key Trial Info
Start Date :
March 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2024
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT06505772
Start Date
March 1 2023
End Date
July 1 2024
Last Update
July 23 2024
Active Locations (1)
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1
University Children's Hospital
Damascus, Syria