Status:
NOT_YET_RECRUITING
Research on Key Technologies for Risk Prediction and Precise Diagnosis and Treatment of AIS Based on Epigene-phenotype
Lead Sponsor:
The First Affiliated Hospital of Zhejiang Chinese Medical University
Conditions:
Adolescent Idiopathic Scoliosis
Eligibility:
All Genders
10-18 years
Phase:
NA
Brief Summary
Mining AIS biomarkers, elucidating the new mechanism of AIS pathogenicity, constructing risk prediction models, optimizing AIS precise diagnosis and treatment techniques, formulating precise diagnosis...
Detailed Description
Currently, there are problems of high genetic and phenotypic heterogeneity in AIS research, lack of in-depth epigenetic studies, and lack of clarity in pathogenic mechanisms. This project proposes to ...
Eligibility Criteria
Inclusion
- Patients diagnosed with AIS;② Sex is not limited, age 10-18 years old; ③ Those who sign the informed consent and can cooperate with follow-up visits; ④ Those who can cooperate with X-ray, chemical test, genetic test and other examination and evaluation for the measurement of relevant indexes.
Exclusion
- Subjects with spine-related diseases such as Marfan's syndrome;
- Subjects with previous ankylosing spondylitis, spinal neurofibroma, spinal tuberculosis, spinal trauma and other spine-related diseases;
- Subjects with combined serious medical diseases and psychiatric patients;
- Those with ECOG score \> 2, which may have an impact on the study results;
- Those who are affected by external factors such as economy, individualized differences, etc., so that they cannot complete the study.
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT06506227
Start Date
September 1 2024
End Date
December 31 2026
Last Update
July 17 2024
Active Locations (1)
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1
Prokin balance apparatus
Hangzhou, Zhejiang, China, 310006