Status:
COMPLETED
Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery
Lead Sponsor:
Xijing Hospital
Conditions:
AKI - Acute Kidney Injury
Delirium, Postoperative
Eligibility:
All Genders
18+ years
Brief Summary
Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis. Therefore, some scholars have propo...
Detailed Description
Approximately 2 million patients undergo cardiac surgery every year, of which approximately 20% to 30% experience cardiac surgery related acute kidney injury (CSA-AKI). At least 3% of CSA-AKI patients...
Eligibility Criteria
Inclusion
- 18 years old and above
- Patients undergone elective cardiac surgery
- History of serum creatinine test within 7 days before surgery
- Provide venous blood samples
- Voluntarily participate and sign an informed consent form
Exclusion
- Patients treated with chronic peritoneum or hemodialysis, prior kidney transplantation, preoperative serum creatinine level\>4.5mg/dL (400 μ mol/L) or end-stage renal disease (defined as glomerular filtration rate\<15ml · min-1 · 1.73m-2)
- Other related diseases that have been previously confirmed to have cognitive impairment, or records of using drugs targeting cognitive impairment during the onset period
- Individuals with severe speech, visual, hearing, or mental impairments that affect cognitive scale assessment
- Individuals with a history of brain tumors, traumatic brain injury, brain parasitic diseases, and other diseases that may cause cognitive impairment
- Individuals with a history of alcohol and drug addiction
- Pregnant and lactating women
Key Trial Info
Start Date :
July 20 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT06508593
Start Date
July 20 2024
End Date
December 31 2024
Last Update
April 6 2025
Active Locations (1)
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1
Xijing Hospital
Xi'an, Shaanxi, China, 710032