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Status:

RECRUITING

Priming Theta Burst Stimulation for Stroke: A Study of Intensity

Lead Sponsor:

The Hong Kong Polytechnic University

Collaborating Sponsors:

Tung Wah Hospital

Conditions:

Stroke

Eligibility:

All Genders

18-75 years

Phase:

NA

Brief Summary

Objectives: To compare the effects of low intensity priming intermittent theta burst stimulation (iTBS) with those derived from conventional intensity priming iTBS, nonpriming iTBS, and sham stimulati...

Detailed Description

Objectives: To compare the effects of low intensity priming intermittent theta burst stimulation (iTBS) with those derived from conventional intensity priming iTBS, nonpriming iTBS, and sham stimulati...

Eligibility Criteria

Inclusion

  • Inclusion Criteria
  • Unilateral upper limb motor dysfunction caused by ischemic stroke, with stroke onset≥6 months. Diagnosis will be verified using discharge summary and radiological reports issued by Hospital Authority. Qualifying participants will undergo structural magnetic resonance imaging (MRI) at the University Research Facility in Behavioral and Systems Neuroscience (UBSN) at PolyU to further confirm their lesion location in the period of experimental participation.
  • Age between 18 and 80 years.
  • Residual upper limb functions between levels 2-6 in the FTHUE, indicating moderately-to-severely impaired upper limb motor functions.
  • Capable of providing informed written consent. Exclusion Criteria
  • Patients who meet any of the following criteria will be excluded:
  • any contraindications to TMS (screened by the safety checklist by Rossi(33)) and/or MRI (screened by the MRI safety checklist offered by UBSN \[see supplement\]).
  • Diagnosed with any concomitant neurological disease other than stroke.
  • signs of cognitive impairment, with a Montreal cognitive assessment score\<21/22 out of 30 (34).
  • Severe spasticity in the hemiparetic upper limb muscles, with a Modified Ashworth score \> 2 (35).

Exclusion

    Key Trial Info

    Start Date :

    July 1 2025

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    September 30 2027

    Estimated Enrollment :

    100 Patients enrolled

    Trial Details

    Trial ID

    NCT06509789

    Start Date

    July 1 2025

    End Date

    September 30 2027

    Last Update

    July 24 2025

    Active Locations (1)

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    1

    Jack Jiaqi Zhang

    Hong Kong, Hong Kong, Hong Kong, 000000