Status:
RECRUITING
Diagnostic Utility of SGLT1/2 Inhibition to Facilitate Myocardial Glucose Suppression
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
Duke University
Conditions:
Cardiac Sarcoidosis
Eligibility:
All Genders
Brief Summary
This is a pilot mechanistic study of the diagnostic utility of sodium-glucose cotransporter-1/2 inhibition (SGLT1/2) on myocardial glucose suppression on FDG PET/CT. The investigators will test whethe...
Detailed Description
The purpose of this mechanistic pilot study is to evaluate the effect on myocardial glucose suppression, and therefore on image quality, with the addition of a brief course of an FDA approved SGLT1/2 ...
Eligibility Criteria
Inclusion
- Adult patients, at least 18 years of age
- No history of cardiovascular disease, including hypertension, hyperlipidemia, diabetes mellitus, heart failure, coronary artery disease, cardiac surgery, arrhythmias per medical record review and/or self-report
- No history of chronic liver or kidney disease per medical record review and/or self-report.
- Participants must be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures.
Exclusion
- Females who are pregnant or breast-feeding will not be eligible for this study. Female participants of child-bearing potential will have a urine pregnancy test during the screening visit and prior to FDG injection.
- Participants who are currently taking diuretics for any indication.
- Participants with an eGFR level \<30 mL/min/1.73m2.
- Inability to tolerate imaging procedures in the opinion of the investigator or treating physician.
- Any other medical or psychological condition that, in the opinion of the investigator would compromise the subject's safety or successful participation in the study.
Key Trial Info
Start Date :
November 20 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06510894
Start Date
November 20 2024
End Date
December 31 2027
Last Update
January 7 2026
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104