Status:
COMPLETED
Sclerostin Regulation in Apical Periodontitis Lesions in Apical Periodontitis Lesions
Lead Sponsor:
Istanbul Medipol University Hospital
Conditions:
Apical Periodontitis
Eligibility:
All Genders
18-65 years
Brief Summary
Our aim was to examine the relationship between inflammatory bone resorption associated with the severity of AP and gingival crevicular fluid (GCF) and blood sclerostin and PGE2 levels in cases of AP....
Detailed Description
Fasting (8-10 hours) venous blood of all participants was taken from forearm antecubital/basic veins. After keeping the blood at room temperature for 30 minutes, it was centrifuged at 2500 xg for 10 m...
Eligibility Criteria
Inclusion
- patients with chronic apical periodontitis having no periodontal pathology having no acute/chronic disease (muscle-joint-bone diseases, inflammatory bowel disease, local or generalized infection, severe organ disease, cardiovascular disease and diabetes mellitus)
Exclusion
- Patients who had any acute/chronic disease (inflammatory and rheumatoid diseases, cardiovascular disease, muscle-joint-bone diseases, inflammatory bowel disease, local or generalized infection, connective tissue diseases and diabetes mellitus) patients who had a history of smoking pregnant and/or lactating patients antibiotics or anti-inflammatory drugs use within the last 6 months patients undergoing dental treatment having chronic marginal periodontitis along with AP patients with a history of using immunosuppressive drugs, steroid or nonsteroidal anti-inflammatory drugs use of high doses of biotin vitamin in the last 48 hours
Key Trial Info
Start Date :
August 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2024
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT06512103
Start Date
August 1 2023
End Date
January 31 2024
Last Update
October 3 2024
Active Locations (1)
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1
Istanbul Medipol University, Faculty of Dentistry
Istanbul, Turkey (Türkiye)