Status:
ACTIVE_NOT_RECRUITING
Hereditary Cerebral Small Vessel Diseases Registry-Trial Ready Cohort
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Cerebral Small Vessel Diseases
Hereditary
Eligibility:
All Genders
Brief Summary
We took hereditary cerebral small vessel disease (hCSVD) patients as our main subjects, aiming to establish a platform for a comprehensive evaluation and long-term follow-up. Deeply explore the pathop...
Detailed Description
Cerebral Small Vessel Disease is a series of clinical, imaging, and pathological syndromes caused by a variety of risk factors affecting cerebral arterioles, arterioles, capillaries, and venules, acco...
Eligibility Criteria
Inclusion
- All ages, male or female
- Carriers of the pathogenic genes mutation (mutation with unknown clinical significance/ suspected pathogenic mutation/ pathogenic mutation) of hCSVD confirmed by the gene tests, including but not limited to NOTCH3, HTPA1, CTSA, GLA, TREX1, COL4A1/2, or highly-suspected hCSVD2
- CSVD related abnormalities on brain MRI, any 1 or more of:
- White matter hyperintensities, Fazekas score3 ≥1
- ≥1 newly-occurred lacunar infarcts
- ≥1 old lacunar infarcts
- ≥3 cerebral microbleeds
- Informed consent signed
Exclusion
- Diagnosis of mental disorders according to DSM-V and unable to be compliant to the research
- Patients with life expectancy less than one year due to any advanced disease, e.g., malignant tumor
- Patients unable to return for follow-up visits due to some reasons
Key Trial Info
Start Date :
July 19 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 19 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06512376
Start Date
July 19 2022
End Date
July 19 2027
Last Update
July 22 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Beijing Tiantan Hospital
Beijing, China, 100050