Status:
RECRUITING
Second Haplo-transplantation for Graft Failure
Lead Sponsor:
Peking University People's Hospital
Collaborating Sponsors:
The First Affiliated Hospital of Soochow University
Ruijin Hospital
Conditions:
Graft Failure
Stem Cell Transplant Complications
Eligibility:
All Genders
14+ years
Phase:
NA
Brief Summary
Graft failure is a fatal complication following allogeneic stem cell transplantation where a second transplantation is usually required for salvage. There are no recommended regimens for second transp...
Eligibility Criteria
Inclusion
- 1\. Primary disease: hematological malignancies (AML, CML, MDS, lymphoma, etc.); 2. Graft failure after the first haploidentical stem cell transplantation; 3. Time from the first transplantation to the second transplantation is less than 180 days; 4. Age≥14 years.
Exclusion
- 1\. Active infections; 2. Active GVHD; 3. Organ dysfunction: hepatic injury (Tbil≥2ULN), renal injury (Cr≥1.5ULN), heart injury (EF%\<50% or symptomatic heart failure); 4. Eastern Cooperative Oncology Group (ECOG) score\>2; 5. Expected life time\<30 days; 5. Patients could not cooperate; 6. Other situations that are considered inappropriate for enrollment by the investigators,
Key Trial Info
Start Date :
July 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT06512519
Start Date
July 1 2024
End Date
June 1 2027
Last Update
November 7 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044