Status:
RECRUITING
Ventilator Pressure and Optimization of Compliance and Hemodynamics
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Bronchopulmonary Dysplasia
Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Eligibility:
All Genders
7-30 years
Phase:
NA
Brief Summary
In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increa...
Detailed Description
In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increa...
Eligibility Criteria
Inclusion
- Preterm infants with recovering respiratory distress syndrome (RDS) who were born at a gestational age \< 34 weeks and are receiving respiratory support via conventional mechanical ventilation or on HFJV.
- Post-natal age \> 7 days and less than 1 month (outside golden week protocol)
- Gestational age ≥ 21 weeks and ≤ 34 week
- Infants with written informed consent obtained from legal guardian
Exclusion
- Blood culture-positive sepsis
- Congenital anomalies affecting respiration
- Cyanotic or ductal-dependent congenital heart disease
- Newborns who are considered too unstable for study enrolment per neonatology attending
- Newborns on pressors or steroids for maintaining cardiac output
- Non-invasive ventilation or newborn with significant BPD (bronchopulmonary dysplasia) with pulmonary hypertension (HTN)
- Open skin wounds or abrasions on the chest wall.
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06512935
Start Date
August 1 2025
End Date
June 30 2026
Last Update
August 8 2025
Active Locations (1)
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1
Univerisity of Alabama
Birmingham, Alabama, United States, 35233