Status:
RECRUITING
Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it
Lead Sponsor:
National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Collaborating Sponsors:
Vilnius University Hospital Santaros Klinikos
Conditions:
Complication of Surgical Procedure
Infections
Eligibility:
All Genders
18+ years
Brief Summary
Infections remain a prevalent complication after major abdominal surgery. The common belief that most surgical site infections (SSIs) following elective surgery with modern antiseptic techniques are d...
Detailed Description
Infections remain a significant concern following major abdominal surgery. The prevailing notion that most surgical site infections (SSIs) after elective surgery with modern antiseptic techniques are ...
Eligibility Criteria
Inclusion
- The patient is scheduled to undergo a major resection-type abdominal surgery due to cancer of the esophagus, stomach, pancreas, liver, bile ducts, colon or rectum.
- Patient is willing to participate.
- Age ≥ 18 years.
Exclusion
- Pregnancy.
- Previous surgical resection of the digestive tract, excluding appendectomy and/or cholecystectomy.
- Anticipated operation with preventive ileostomy.
- The operation is planned to be performed as a matter of urgency.
- Antibiotic therapy ≤1 month. before surgery.
- Chronic inflammatory bowel disease (non-specific ulcerative colitis, Crohn's disease) or radiation or other colitis of origin.
- During the last year, the patient suffered from Cl. difficile colitis or was Cl. difficile carrier, had salmonellosis or others intestinal infections.
- During the last year, the patient used (\> 3 months) pre-/pro-/(syn)biotics.
- During the last year, the patient has been taking proton pump inhibitors continuously (\> 6 months).
Key Trial Info
Start Date :
July 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2029
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06513598
Start Date
July 1 2024
End Date
May 1 2029
Last Update
August 1 2024
Active Locations (2)
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1
National Cancer Institute
Vilnius, Lithuania
2
Vilnius University hospital Santaros Klinikos
Vilnius, Lithuania