Status:
RECRUITING
Prognostic Biomarkers for Pulpotomy Outcome
Lead Sponsor:
The University of Hong Kong
Conditions:
Pulpitis - Irreversible
Eligibility:
All Genders
Phase:
NA
Brief Summary
This study will recruit 180 molars diagnosed with irreversible pulpitis. Full pulpotomy will be performed on 120 teeth, while RCT (root canal treatment) will be conducted on another cohort of 60 teeth...
Eligibility Criteria
Inclusion
- Permanent molars showing clinical and radiographic evidence of a deep carious lesion (extend to the three-quarters thickness of dentine radiographically) extending close to the pulp chamber
- Clinical diagnosis of irreversible pulpitis, including spontaneous pain, lingering pain with cold stimulation, no or mild tenderness to percussion, normal apical tissue or widening of the periodontal ligament space but with no signs of periapical periodontitis (i.e., PAI score 1 or 2)
- Positive response to cold and electric pulp test.
Exclusion
- Tooth with no response to the cold and electric tests, presence of apical radiolucency (greater than periodontal widening), signs of canal calcification and resorption, history of trauma, unrestorable or nonfunctional teeth, and evidence of perio-endo lesion
- Intraoperative bleeding time is more than 10 minutes or less than 10 μL pulpal blood can be obtained
- Patients with a compromised immune status (such as HIV or organ transplant) or with any history of taking analgesics/antibiotics in the past one week.
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
192 Patients enrolled
Trial Details
Trial ID
NCT06514053
Start Date
January 1 2024
End Date
December 1 2026
Last Update
July 23 2024
Active Locations (1)
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1
Clinical Research Centre, Faculty of Dentistry, The University of Hong Kong
Hong Kong, Hong Kong