Status:
RECRUITING
Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
Lead Sponsor:
Southeast University, China
Conditions:
ARDS
Lung Protective Ventilation
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse alveolar injury caused by a variety of pulmonary and extrapulmonary factors, leading to refractory hypoxemia. It has high i...
Eligibility Criteria
Inclusion
- Patients with moderate to severe ARDS requiring the use of NMBAs, as assessed by clinicians (Berlin definition 2012: PaO2/FiO2 \< 150 mmHg, PEEP ≥ 5).
- Age: 18-85 years.
- Signed informed consent.
Exclusion
- History of allergy to NMBAs.
- Open chest or abdominal injuries.
- Patients with pulmonary masses, lung transplantation, or lung resection.
- Contraindications to esophageal catheter placement.
- Pregnant patients.
- Contraindications to TOF measurement (e.g., history of neuromuscular disease, presence of a cardiac pacemaker).
- Severe dysfunction of other organs with an expected short-term mortality (within 7 days) or palliative care.
- Previous inclusion in this study.
Key Trial Info
Start Date :
June 28 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06514209
Start Date
June 28 2024
End Date
June 30 2025
Last Update
July 23 2024
Active Locations (1)
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1
Zhongda Hospital, Affiliated to Southeast University
Nanjing, Jiangsu, China