Status:
RECRUITING
Vaccine Immunity and Inflammation in the Aging Person Living With HIV
Lead Sponsor:
Hennepin Healthcare Research Institute
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
HIV Infections
Age
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study will track immune responsiveness to conjugate pneumococcal vaccines over time to help determine how long protection from this vaccine lasts in individuals with chronic medical conditions (i...
Detailed Description
Persons living with HIV (PLWH) are at increased risk of chronic inflammation and the associated adverse health outcomes. There is considerable evidence that chronic inflammatory conditions like metabo...
Eligibility Criteria
Inclusion
- Age\>=18 years
- HIV Diagnosis
- On Antiretroviral Therapy with HIV Viral Load\<200 within last year
Exclusion
- Other significant immunosuppressing condition
- Age\< 18 years
- Pregnancy (at enrollment)
- Contraindication to pneumococcal vaccination
- Known contraindication to non-clinical blood draws (severe anemia last hemoglobin \<8g/dl)
- Subjects who, in the opinion of the Investigator, may be non-adherent to study schedules or procedures.
- Adults unable to consent
- Individuals with impaired ability to consent
- Incarceration at time of enrollment
- Controls inclusion criteria:
- Age\>=18 years
- HIV Ag-Ab test negative
Key Trial Info
Start Date :
July 8 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06514547
Start Date
July 8 2024
End Date
June 30 2029
Last Update
June 12 2025
Active Locations (1)
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1
Hennepin Healthcare System
Minneapolis, Minnesota, United States, 55415