Status:
RECRUITING
Exercise Magnetic Resonance Imaging in Patients With Obesity Associated Heart Failure
Lead Sponsor:
University Medical Center Groningen
Conditions:
HFpEF - Heart Failure With Preserved Ejection Fraction
Eligibility:
All Genders
18+ years
Brief Summary
To aim of the EXPOSURE study is to investigate the effects of epicardial fat on cardiac function, pericardial constraint and pulmonary artery vasodilatation using cardiac magnetic resonance (CMR) imag...
Detailed Description
The EXPOSURE study investigates the effects of epicardial fat on ventricular interdependence at peak exercise. Epicardial fat, the visceral fat situated directly adjacent to the heart, seems involved ...
Eligibility Criteria
Inclusion
- Signs and symptoms of HF according to the Europeans Society of Cardiology guideline.
- LV ejection fraction ≥40%.
- HFA-PEFF score ≥5 or HFA-PEFF score 2-4 in combination with positive stress test (Figure 1).
- \>18 years of age
- In sinus rhythm
- Able to perform a bicycle exercise test
- Willing to sign informed consent
Exclusion
- Body weight \>140 kg
- Atrial fibrillation or other significant arrhythmia during the assessment
- Contraindications for CMR (e.g. claustrophobia, implanted cardiac devices)
- Myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft \<3 months or untreated severe obstructive coronary artery stenosis
- More than moderate left-sided valve disease.
- Complex congenital heart disease.
Key Trial Info
Start Date :
January 16 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06514820
Start Date
January 16 2024
End Date
December 31 2025
Last Update
July 23 2024
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands, 9713GZ