Status:
COMPLETED
AGE/sRAGE Ratio in Diabetic Periodontitis
Lead Sponsor:
Hacettepe University
Conditions:
Periodontitis, Diabetes Mellitus Type 2
Eligibility:
All Genders
25-74 years
Brief Summary
The goal of this observational study is to learn about some molecules in the disease mechanism of type 2 diabetes and periodontitis. There are end products inside the body called AGEs and their recept...
Eligibility Criteria
Inclusion
- Having interdental attachment loss in at least two non-adjacent teeth, or with \>3 mm of attachment loss in the buccal or palatal/lingual region with \>3 mm probing depth in at least two teeth for periodontitis groups.
- Having minimum 5mm or more pocket depth in at least 6 periodontal pockets.
- HbA1c value ≤ 6.5% and fasting blood sugar levels \<200 mg/dl for the controlled diabetes group.
- HbA1c value \> 6.5% and fasting blood sugar levels \> 200 mg/dl for uncontrolled diabetes group.
Exclusion
- having periodontal treatment in the last six months;
- participants with smoking habit or history; and
- usage of medicine that may affect study results (mouthwash, antibiotics, corticosteroid, statins etc.) three months before collecting dental plaque and GCF samples.
- Lactating or pregnant patients
- Patients with systemic diseases other than type 2 diabetes.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 10 2023
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06516328
Start Date
May 1 2022
End Date
December 10 2023
Last Update
July 23 2024
Active Locations (1)
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1
Hacettepe University
Ankara, Turkey (Türkiye), 06100