Status:
COMPLETED
Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia
Lead Sponsor:
Tamas Vegh, MD
Conditions:
Residual Neuromuscular Block
Cardiovascular Diseases
Eligibility:
All Genders
18-65 years
Brief Summary
Deep neuromuscular block (DNMB) during laparoscopy induces less haemodynamic stress by facilitating low-pressure pneumoperitoneum. the investigators tested the feasibility of pipecuronium-induced deep...
Detailed Description
Patients with a high cardiovascular risk who undergo lparoscopic cholecystectomy before cardiac surgery were included in the study. It is known from the literature that low pressure pneumoperitoneum h...
Eligibility Criteria
Inclusion
- high cardiovascular risk, class III- IV, according to the New York Heart Association classification of heart failure
- Age: between 18- 65 years old.
- ASA (American Society of Anesthesia score) 1- 3
- BMI between 18.5- 25
- Laparoscopic surgical interventions
- Endotracheal intubation
- Patient in supine position on operating table with one arm abducted and accessible.
Exclusion
- Patients with diseases affecting neuromuscular functions (myopathies, severe liver and kidney failure).
- Patients on medications affecting the neuromuscular function (magnesium,aminoglycosides).
- Difficult airway or anticipated difficult airway.
- pregnancy (a pregnancy test was performed for every female patient in childbearing age to rule out pregnancy);
- Breastfeeding
- Acute surgical indications
- Chronic Obstructive Pulmonary Disease (COPD)
- Glaucoma
Key Trial Info
Start Date :
January 8 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 5 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06517524
Start Date
January 8 2023
End Date
June 5 2024
Last Update
July 24 2024
Active Locations (1)
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1
University of Debrecen
Debrecen, Hajdú-Bihar, Hungary, 4032