Status:

RECRUITING

Modified Aortic Root Enlargement Procedure

Lead Sponsor:

China National Center for Cardiovascular Diseases

Conditions:

Small Aortic Annulus

Aortic Root Enlargement Procedure

Eligibility:

All Genders

50-70 years

Brief Summary

This study is a prospective observational clinical trial, in which severe AS patients aged 50-70 years with SAA choose modified ARE or TAVR according to their wishes to investigate the safety and effi...

Detailed Description

Small aortic annulus (SAA), which is prevalently observed in patients with severe aortic stenosis (AS), constitutes a significant challenge in treatment and may give rise to post-operative prosthetic ...

Eligibility Criteria

Inclusion

  • 1\) Symptomatic severe AS patients aged 50-70 years who are planning to undergo biological valve replacement (diagnostic criteria for echocardiography are: mean transvalvular pressure gradient ≥ 40mmHg or flow velocity ≥ 4.0 m/s, aortic valve area (AVA) ≤ 0.8 cm2 or iEOA\<0.5 cm2/m2) 2) Merge SAA (defined as mean aortic annulus diameter ≤ 23 mm measured by CT)

Exclusion

  • 1\) High surgical risk, STS score\>8% 2) Severe lesions in multiple coronary arteries requiring PCI or CABG 3) Simultaneous surgical intervention is required for severe mitral and tricuspid valve disease 4) Combining other complex cardiovascular diseases requires simultaneous surgical treatment 6) Combined severe pulmonary arterial hypertension or left ventricular dysfunction (LVEF\<40%) 7) Severe respiratory, liver and kidney dysfunction, or other important organ dysfunction combined 8) Concurrent infective endocarditis in active phase 9) Previous history of cardiac surgery

Key Trial Info

Start Date :

July 15 2024

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2026

Estimated Enrollment :

64 Patients enrolled

Trial Details

Trial ID

NCT06517537

Start Date

July 15 2024

End Date

December 31 2026

Last Update

August 27 2024

Active Locations (1)

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1

Fuwai Hospital

Beijing, Beijing Municipality, China