Status:
ACTIVE_NOT_RECRUITING
A Prospective, Observational Study in Adults With Retinitis Pigmentosa (RP)
Lead Sponsor:
Sumitomo Pharma America, Inc.
Conditions:
Retinitis Pigmentosa
Eligibility:
All Genders
18+ years
Brief Summary
The natural history in individuals with severe retinitis pigmentosa (RP) is variable and there remains an unmet need to better understand disease progression in this population. The goal of this study...
Detailed Description
This is a 12-month, single-center, prospective observational study in adults with RP. Approximately 12 subjects will be enrolled into the Observation Period. The primary objective of this study is to...
Eligibility Criteria
Inclusion
- Subject is ≥ 18 years of age at the time of informed consent.
- Subject has a clinical diagnosis of nonsyndromic retinitis pigmentosa.
- Subject is willing to consent to genetic testing, if not already done.
- Subject has BCVA in the worse eye between hand motion and 35 Early Treatment of Diabetic Retinopathy Study (ETDRS) letter score (approximately ≤ 20/200 Snellen equivalent), inclusive.
- Subject has a central visual field diameter (ie, excluding temporal islands) of \< 20 degrees in the worse eye as measured with the V4e stimulus using kinetic perimetry.
Exclusion
- Subject has an eye disease or visual disorder other than retinitis pigmentosa that impairs visual function.
- Subject has any other eye condition, which in the opinion of the Investigator, would preclude an accurate evaluation at any time during the study.
- Subject has any clinically significant unstable medical condition or any clinically significant chronic disease that in the opinion of the Investigator, would limit the subject's ability to complete and/or participate in the study.
- Subject has received treatment with any nonapproved, experimental, or investigational therapy in either eye (systemic, topical, intravitreal) and/or received treatment in an interventional clinical trial for an eye disease or disorder within 90 days or 5 half-lives, whichever is longer, prior to Screening or anticipates the need to receive treatment in an interventional clinical trial during their participation in this study.
- Subject has previously received cell therapy, gene augmentation therapy, genome editing therapy, or any subretinal administered therapy for an eye disease or disorder or anticipates the need for these therapies during their participation in this study.
- Subject has previously received LUXTURNA (voretigene neparvovec-rzyl) or anticipates the need for this therapy during their participation in this study.
Key Trial Info
Start Date :
October 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 28 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06517940
Start Date
October 3 2024
End Date
February 28 2026
Last Update
September 19 2025
Active Locations (1)
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1
Mass Eye and Ear
Boston, Massachusetts, United States, 02114