Status:
NOT_YET_RECRUITING
Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma
Lead Sponsor:
Universidade do Porto
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
45+ years
Phase:
PHASE4
Brief Summary
This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic). Patients will be selected with t...
Detailed Description
A prospective cohort clinical study. The matched sample will be divided into two groups. Group 1 will receive two intraosseous injections of PRP and another intra-articular injection of PRP on the sam...
Eligibility Criteria
Inclusion
- Adult individuals with unilateral or bilateral symptomatic knee OA diagnosis according to the American College of Rheumatology
- with symptoms for more than 3 months
- confirmed with radiologic diagnosis (Kellgren-Lawrence grades III or IV).
- Patients must be able to walk with a painful knee.
Exclusion
- previous history of knee surgery
- systemic autoimmune or rheumatic disease
- platelet diseases
- use of NSAIDs 3 days prior the injections
- previous history (last 3 months) of systematic use of corticosteroids
- or other intra-articular injections in the knee in the past 6 months
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06520059
Start Date
January 1 2025
End Date
October 31 2027
Last Update
August 6 2024
Active Locations (2)
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1
Faculdade de Medicina da Universidade do Porto
Porto, Portugal, 4200 - 319
2
Faculdade de Medicina da Universidade do Porto
Porto, Portugal, 4200-319