Status:
COMPLETED
Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury
Lead Sponsor:
University of Florida
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
21-80 years
Phase:
NA
Brief Summary
Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particula...
Detailed Description
Recent studies have found that acute intermittent hypoxia (AIH)-or repetitive exposure to brief episodes of low inspired oxygen--is a promising new strategy that can help restore motor function by pro...
Eligibility Criteria
Inclusion
- Adults aged 21-80 years
- A mild to moderate traumatic brain injury (TBI) confirmed by medical records
- A Glasgow Coma Scale score between 9-15
- Able to consent independently
- Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study
Exclusion
- Other neurological diagnoses or a diagnosis of a severe psychiatric disorder
- Severe aphasia preventing a participant from understanding the protocol and consent form
- Pre-existing hypoxic pulmonary disease
- History of obstructive lung diseases such as chronic obstructive pulmonary disease (COPD) or significant asthma)
- Severe hypertension (\>160/100)
- History of head and neck cancer
- Allergy to barium sulfate
- Ischemic cardiac disease
Key Trial Info
Start Date :
August 30 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2025
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT06520358
Start Date
August 30 2024
End Date
September 30 2025
Last Update
January 9 2026
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Florida
Jacksonville, Florida, United States, 32209