Status:
NOT_YET_RECRUITING
Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Head and Neck Cancer
Anesthesia
Eligibility:
All Genders
18-99 years
Phase:
PHASE4
Brief Summary
This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in hea...
Detailed Description
This study investigates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with a multimodal analgesia strategy using dexmedetomidine, ketamine, and li...
Eligibility Criteria
Inclusion
- Age 18-99 years
- Scheduled for head and neck cancer tumor resection and free flap reconstruction surgery
Exclusion
- Preoperative tracheostomy
- History of previous head and neck cancer tumor resection
- Anemia (hematocrit \<30% or recent transfusion)
- Hypertension on ACEI/ARB medications
- Significant medical conditions (e.g., NYHA class 3 or 4 heart failure, eGFR \<60 ml/min/1.73 m², Child B or C liver failure, severe respiratory disorders, pre-existing cognitive impairment)
- ASA physical status 4 or 5
- Allergies to sevoflurane, dexmedetomidine, ketamine, or lidocaine
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06521697
Start Date
August 1 2024
End Date
December 1 2025
Last Update
July 26 2024
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.