Status:
RECRUITING
A Study of Barrett's Esophagus Patients to Investigate Quality of Life and Fear of Cancer, and Optimize a Risk Model Based on Biomarkers and New Technologies to Better Predict the Development of Cancer
Lead Sponsor:
University Hospital, Antwerp
Collaborating Sponsors:
Karolinska Institutet
Universal Diagnostics
Conditions:
Barrett's Esophagus
Esophageal Adenocarcinoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study serves, in part, to prepare for a future large cohort study. The goal of the study is: 1. The collection of various tissue samples (blood, biopsies and "esophageal brushes") and their anal...
Detailed Description
More specifically, you will have a standard endoscopy twice during which tissue samples will be taken from the esophagus to check for the severity of the disease. This is part of standard care. If you...
Eligibility Criteria
Inclusion
- Patients with known BE undergoing endoscopy for possible treatment by EMR or ESD due to suspicion of early esophageal Barrett cancer
- Capable of receiving informed consent and of giving permission
- Age 18 and upward
Exclusion
- Patients with current known malignancy of the gastrointestinal tract other than the esophageal lesion
- Patients with severe co-morbidity that prohibits endoscopic therapy under sedation or conscious sedation (such as severe cardiac or pulmonary disease)
- Esophageal varices
- Uncontrollable coagulation disorders
- Undergoing chemotherapy or immunotherapy or received chemotherapy \< 6 weeks prior to endoscopy
- Undergoing radiotherapy within the esophageal region or received chemotherapy \< 6 months prior to endoscopy
- WHO score \> 3
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06523374
Start Date
July 1 2025
End Date
December 1 2026
Last Update
July 11 2025
Active Locations (9)
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1
University Hospital Antwerp
Edegem, Antwerpen, Belgium, 2650
2
Sint-Augustinus Hospital (ZAS)
Wilrijk, Antwerpen, Belgium, 2610
3
UZ Gent
Ghent, Belgium, 9000
4
AZ Delta
Roeselare, Belgium, 8800