Status:
RECRUITING
Prediction of Decompensation and HCC Development in Advanced Chronic Liver Disease
Lead Sponsor:
University Hospital Muenster
Conditions:
Liver Diseases
Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this observational study is to predict the short- and long-term development of acute severe disease events, de novo hepatocarcinoma (HCC) and mortality in patients with advanced chronic liv...
Detailed Description
Patients who are hospitalized with advanced chronic liver disease are randomly divided into two groups. Patients in the control group are examined according to the current clinical standard protocol ...
Eligibility Criteria
Inclusion
- The patient admitted/referred to study center is hospitalized or is an outpatient with advanced chronic liver disease (based on the BAVENO criteria)
Exclusion
- Pregnancy
- Age \<18
- Evidence of current malignancy except for non-melanocytic skin cancer
- Presence or history of severe extra-hepatic diseases (e.g., chronic renal failure requiring hemodialysis, severe heart disease (New York Heart Association (NYHA) \> II); severe chronic pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease (GOLD) \> III), severe neurological and psychiatric disorders).
- Human Immunodeficiency Virus (HIV) positive patients.
- Previous liver or other transplantation.
- Patients who decline to participate or who cannot provide prior written informed consent and when there is documented evidence that the patient has no legal surrogate decision maker and it appears unlikely that the patient will regain consciousness or sufficient ability to provide delayed informed consent.
- Physician's denial (e.g. the investigator considers that the patient will not follow the protocol scheduled).
Key Trial Info
Start Date :
September 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT06523608
Start Date
September 1 2024
End Date
September 1 2027
Last Update
December 22 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Hospital Muenster
Münster, North Rhine-Westphalia, Germany, 48149