Status:
WITHDRAWN
Effect of Neuronavigated Theta-Burst Transcranial Magnetic Stimulation (TBS) for Early Alzheimer's Disease
Lead Sponsor:
Anhui Medical University
Conditions:
Alzheimer Disease
Transcranial Magnetic Stimulation
Eligibility:
All Genders
45-85 years
Phase:
NA
Brief Summary
Comparison of the therapeutic effects of two neuronavigated theta-pulse transcranial magnetic stimulation in patients with Alzheimer's disease and their underlying neural mechanisms
Detailed Description
All patients underwent a series of medical assessments that included physical examination and routine laboratory studies before and after repetitive transcranial magnetic stimulation (rTMS) treatment....
Eligibility Criteria
Inclusion
- Subject diagnosed with early Alzheimer's disease or related diseases according to NINCDS-ACDRADA criteria.
- Subjects must have a MMSE score between 15 and 27,indicating mild cognitive impairment or dementia.
- CDR score ≤ 1.
- Subject under treatment by IAChE for at least 3 months.
- psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months.
Exclusion
- CDR \> 1.
- Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
- History of head injury,stroke,or other neurologic disease.
- Organic brain defects on T1 or T2 images.
- History of seizures or unexplained loss of consciousness.
- Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator.
- Family history of medication refractory epilepsy.
- History of substance abuse within the last 6 months.
Key Trial Info
Start Date :
September 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 10 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT06524817
Start Date
September 10 2023
End Date
March 10 2025
Last Update
April 1 2025
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032