Status:
NOT_YET_RECRUITING
Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
Lead Sponsor:
Capital Medical University
Conditions:
Critical Care
Acute Hypoxic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support set...
Detailed Description
Pressure-support ventilation (PSV) is widely used in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the ventilator suppor...
Eligibility Criteria
Inclusion
- Mechanically ventilated patients, who are admitted to the ICU with acute hypoxic respiratory failure, will be consecutively screened daily at 08:00-10:00 morning rounds.
- Inclusion criteria:
- PSV initiated during the last 24 hours;
- The partial pressure of oxygen in arterial blood (PaO2)/inspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure PEEP);
- Stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.
- Exclusion criteria included:
- Age younger than 18 years old;
- Initiation of PSV before ICU admission;
- Duration of mechanical ventilation longer than 7 days before enrollment;
- History of neuromuscular diseases;
- Clinical suspicion of increased intracranial pressure;
- Extracorporeal support;
- Moribund conditions;
- Refusal by the ICU physicians or the patient.
Exclusion
Key Trial Info
Start Date :
September 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
640 Patients enrolled
Trial Details
Trial ID
NCT06526598
Start Date
September 1 2024
End Date
September 30 2026
Last Update
July 30 2024
Active Locations (1)
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1
Beijing Shijitan Hospital
Beijing, Beijing Municipality, China, 100038