Status:
TERMINATED
Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb
Lead Sponsor:
Third Affiliated Hospital of Zhengzhou University
Conditions:
Pregnancy Related
Thyroid Stimulating; Hormone, C
Eligibility:
FEMALE
Brief Summary
The purpose of this clinical trial is to understand the impact of different doses of levothyroxine on the immune inflammatory response in pregnant women with normal-high TSH and positive TPOAb in the ...
Detailed Description
To explore the correlation between different doses of levothyroxine (LT4) supplementation and Th17/Treg and cytokines in pregnant women with normal-high thyroid stimulating hormone (TSH) and positive ...
Eligibility Criteria
Inclusion
- Thyroid function level meets the specific reference range established by the laboratory department of our hospital based on the "Guidelines for the prevention and management of thyroid diseases during pregnancy and perinatal period" : FT4: 12-22pmol/L; disease group: TPOAb\>;34IU/mL, TSH: 2.5mIU/L-upper limit of reference range; control group: TPOAb≤34IU/mL, TSH\<2.5mIU/L;
- All pregnant women are in the first half of pregnancy (gestational age≤20 weeks).
Exclusion
- Combined with hypothyroidism, subclinical hypothyroidism, and hyperthyroidism;
- Assisted reproduction;
- Multiple pregnancy;
- Combined with other autoimmune diseases such as antiphospholipid syndrome and thrombophilia;
- Severe intestinal diseases or intestinal surgery history, or the use of probiotics, prebiotics and other drugs that affect intestinal flora;
- Obesity, pre-pregnancy hyperlipidemia;
- Adverse reactions to LT4
Key Trial Info
Start Date :
April 6 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 5 2024
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06527859
Start Date
April 6 2022
End Date
June 5 2024
Last Update
July 30 2024
Active Locations (1)
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1
The Third Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China