Status:
RECRUITING
Proteinopathies Expression in Skin of Neurodegenerative Disorders
Lead Sponsor:
Universidad Autonoma de San Luis Potosí
Collaborating Sponsors:
Hospital Central "Dr. Ignacio Morones Prieto"
Conditions:
Alzheimer Disease
Frontotemporal Dementia
Eligibility:
All Genders
45+ years
Brief Summary
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 \[TDP4...
Detailed Description
Alzheimer's disease is the main cause of neurodegenerative dementia and represents a high degree of morbidity and mortality among the patients who have it, causing a great economic impact in health sy...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients:
- Patients 45 years and older
- Men and women
- Patients diagnosed with Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus
- Patients that voluntarily accept to participate in the study and accept the consent form
- Inclusion Criteria healthy control subjects:
- People 45 years and older
- Men and women
- Subjects can be related to a patient but not by blood (for example spouse of a patient)
- Subjects don't have direct family history of a neurodegenerative control
- Subjects don't have any clinical findings suggesting dementia
- Subjects voluntarily accept to participate in the study and accept the consent form
- Exclusion Criteria:
- Patients or controls that have a personal history of cerebrovascular disease, psychiatric disease, post traumatic dementia or HIV related dementia
- Patients in which the diagnosis is not clear or hasn't been confirmed
- Patients or controls that have a neuroinfection
- Patients or controls that a diagnosed skin disease
- Patients that have an "atypical" presentation of the disease
- Patients or controls that have diagnosis of a coagulopathy
Exclusion
Key Trial Info
Start Date :
December 20 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06528964
Start Date
December 20 2023
End Date
November 1 2026
Last Update
December 16 2024
Active Locations (1)
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1
Hospital Central Dr. Ignacio Morones Prieto
San Luis Potosí City, Mexico, 78290