Status:
RECRUITING
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Sunnybrook Health Sciences Centre
Baycrest
Conditions:
Dementia
Alzheimer Disease
Eligibility:
All Genders
30-95 years
Brief Summary
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurod...
Detailed Description
The goal of this study is to create a model to predict disease progression in patients with mild cognitive impairments and forms of dementia. To accomplish this, the current study will evaluate differ...
Eligibility Criteria
Inclusion
- Possible or probable diagnosis of MCI or early dementia
- Age 30-95
- Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
- Must, in the opinion of the site investigator, be able to complete most study procedures.
Exclusion
- Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Key Trial Info
Start Date :
November 11 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06529744
Start Date
November 11 2023
End Date
November 1 2027
Last Update
November 20 2025
Active Locations (4)
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1
Baycrest
North York, Ontario, Canada, M6A 2E1
2
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
3
Toronto Western Hospital, University Health Network
Toronto, Ontario, Canada, M5T 2S8
4
Centre for Addiction and Mental Health
Toronto, Ontario, Canada, M6J 1H1