Status:
RECRUITING
Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study
Lead Sponsor:
Bispebjerg Hospital
Collaborating Sponsors:
University of Copenhagen
Conditions:
Coronary Microvascular Disease
CMD
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical e...
Detailed Description
A significant number of patients suspected of chronic coronary syndrome do not have coronary artery obstruction and in a large proportion of these, their symptoms are attributed to coronary microvascu...
Eligibility Criteria
Inclusion
- Coronary microvascular dysfunction, defined as myocardial bloodflow reserve (MBFR) \< 2.5 or hyperemic myocar-dial blood flow (hMBF)\<2.3 ml/g/min using \[15O\]H2O-PET
- No obstructive coronary artery disease
Exclusion
- Females of childbearing potential (defined as a premeno-pausal female capable of becoming pregnant). The female patient must either be postmenopausal, defined as amen-orrhea for at least 1 year, or surgically sterile
- Heart failure, defined as left ventricular ejection fraction of less than 40%
- Uncontrolled hypertension defined as blood pressure above target 140/90 for all
- Co-morbidity resulting in \<1 year expected survival
- Considered by the investigator, for any reason, to be an un-suitable candidate for the study.
- Unable or unwilling to exercise, e.g. due to arthritis or in-jury\*
- Already are regularly physically active and/or have a maxi-mal oxygen uptake \>45 ml/kg/min
Key Trial Info
Start Date :
November 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 15 2028
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06529848
Start Date
November 1 2024
End Date
May 15 2028
Last Update
February 21 2025
Active Locations (2)
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1
Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57, Frederiksberg, Denmark, 2000
Copenhagen, Denmark, 2400
2
Frederiksberg Hospital, Dept. of Cardiology, Building 16, Y3, Nordre Fasanvej 57
Frederiksberg, Denmark, 2000