Status:
RECRUITING
Deep Cervical Lymphatlc-Venous Anastomosis Surgery for the Treatment of Alzheimer's Disease: A Pilot Study (DIVA Study)
Lead Sponsor:
Zhejiang Provincial People's Hospital
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
Phase:
PHASE3
Brief Summary
The goal of this clinical trial is to To demonstrate the Safety and Efficacy of dcLVA Surgery for the Treatment of Alzheimer's Disease. Patients who meet the inclusion and exclusion criteria and conse...
Detailed Description
This study aims to enroll patients diagnosed with AD. Patients who meet the inclusion and exclusion criteria and consent to participate will be randomly assigned to either the experimental group (rece...
Eligibility Criteria
Inclusion
- Diagnosed as an AD patient according to biological markers and clinical symptoms;
- Over 35 years old and with an MMSE or MOCA score ≤ 26;
- The patient or family member has signed an informed consent form.
Exclusion
- Inability to cooperate with lumbar puncture;
- Cognitive impairment due to neurological infections (e.g., HIV, neurosyphilis, autoimmune encephalitis) or systemic diseases (e.g., diabetes, thyroid dysfunction);
- Significant organ dysfunction (heart, lung, liver, kidney);
- Coagulation disorders or contraindications to surgery;
- Inability to fully cooperate with follow-up visits.
Key Trial Info
Start Date :
July 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06530732
Start Date
July 1 2024
End Date
September 30 2026
Last Update
January 16 2025
Active Locations (1)
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1
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China, 310014