Status:
RECRUITING
The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis
Lead Sponsor:
Jordan University of Science and Technology
Conditions:
Meniscus Tear
Eligibility:
All Genders
35-55 years
Phase:
NA
Brief Summary
This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degener...
Detailed Description
Background: Degenerative meniscus tears are common in individuals over 35 and are associated with early stages of knee osteoarthritis (OA) (1,2). Metabolic and microstructural changes within the carti...
Eligibility Criteria
Inclusion
- Are between 35 and 55 years of age.
- Have a symptomatic degenerative medial meniscus tear as evidenced by:
- Presence of medial knee pain.
- Medial joint line tenderness.
- Pain and limited motion when attempting to perform a full squat and
- Increased intra-meniscal signal on at least 2 consecutive MRI slices and
- Have clearance from their personal physician to participate in an exercise program.
Exclusion
- Radiographic evidence of OA (K-L grade 2 or above).
- A repairable meniscus injury (longitudinal tear in the outer 1/3 of the meniscus).
- A meniscus injury that requires meniscectomy (locked knee).
- Prior or current ligament injury or surgery of the involved knee.
- Prior or current injury or surgery to contra-lateral knee.
- Pathological ligamentous laxity upon examination of the knee
- An inflammatory arthritic condition or
- Any injury or condition involving the lower extremities that affects their ability to walk.
- Because participation in this study requires undergoing MRI, subjects will be excluded if they:
- If female, pregnant at the time of enrollment.
- Had prior surgery for an aneurysm; any medical illness that may interfere with the patient's general fitness or exercise capability.
- Had any contraindication with MRI.
- Had surgery within the past two months.
- Have a cardiac pacemaker.
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2029
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT06532851
Start Date
January 1 2024
End Date
October 1 2029
Last Update
August 1 2024
Active Locations (2)
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1
King Abdullah University Hospital
Ar Ramtha, Jordan
2
Jordan University of Science and Technology
Irbid, Jordan