Status:
ACTIVE_NOT_RECRUITING
Melatonin Epigenetic Potential in Preventing Malignant Transformation of Oral Lichen Planus
Lead Sponsor:
Hams Hamed Abdelrahman
Conditions:
Oral Lichen Planus
Eligibility:
All Genders
25-65 years
Phase:
NA
Brief Summary
Background: Oral Lichen planus (OLP) is one of the most common oral diseases that has an unneglectable rate of malignant transformation. Recently malignant transformation has been definitively linked ...
Eligibility Criteria
Inclusion
- Patients clinically and histopathologically diagnosed to be suffering from OLP in the following forms has been reported in the literature to have the highest potentiality for malignant transformation (plaque-type lichen , Erosive lichen planus, ulcerative lichen planus), with or without histopathological dysplasia.
- Patients who have symptoms (i.e. pain and burning sensation) secondary to OLP.
Exclusion
- Patients suspected to have lichenoid drug reaction or lichenoid contact allergy.
- Patients suffering from systemic diseases (such as diabetes, cardiovascular or liver disorders, renal dysfunction).
- Patients with findings of any physical or mental abnormality that would interfere with or be affected by the study procedure.
- Patients who have adverse habits of chewing tobacco and smoking.
- Pregnant and lactating women.
- Patients under treatment with corticosteroids and immunosuppressants.
- Patients exhibiting any skin manifestations of OLP
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06533033
Start Date
January 1 2024
End Date
August 1 2024
Last Update
August 1 2024
Active Locations (1)
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1
Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt