Status:
COMPLETED
Parameters of Cardiac Indices on the Ultrasonic Cardiac Output Monitor As Potential Indicators for Predicting the Achievement of Ultrafiltration Endpoint for Acute Heart Failure Treatment
Lead Sponsor:
Shanghai Tong Ren Hospital
Conditions:
Acute Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Background: The feasibility of the ultrasonic cardiac output monitor (USCOM)applying for determining ultrafiltration (UF) endpoints during acute heart failure (AHF) treatments was evaluated. Methods:...
Detailed Description
This study was based on the ACC/AHA/HFSA guidelines for the management of heart failure and involved 40 patients diagnosed with acute decompensated heart failure (ADHF) from January 2022 to July 2023....
Eligibility Criteria
Inclusion
- Age ≥ 18 years.
- Male or non-pregnant female patients.
- Fluid overload manifested by at least two of the following:
- Pitting edema ≥ 2+ of the lower extremities
- Moist rales in the lungs
- Jugular venous distention \> 10 cm
- Pulmonary edema or pleural effusion on chest x-ray
- Paroxysmal nocturnal dyspnea or ≥ two-pillow orthopnea
- Congestive hepatomegaly or ascites
- B-type natriuretic peptide (BNP) \> 400 pg/mL
Exclusion
- Hematocrit \> 45%.
- Systolic blood pressure ≤ 90 mmHg and poor peripheral circulation.
- Contraindications to heparin anticoagulation.
- Renal insufficiency with a Scr ≥ 3.0 mg/dl or planned renal replacement therapies.
- Acute coronary syndromes.
- Life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Active myocarditis.
- patients with heart failure attributed to restrictive or hypertrophic cardiomyopathy or uncorrected valvular stenotic disease.
- infection.
- malignancies.
- systemic immune disease.
- unwillingness to cooperate.
- withdrawal from the study or death.
Key Trial Info
Start Date :
January 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06533124
Start Date
January 5 2022
End Date
August 1 2023
Last Update
August 1 2024
Active Locations (1)
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1
ShanghaiTongren Hospital
Shanghai, Shanghai Municipality, China, 200336