Status:
COMPLETED
Effects of Anthriscus Sylvestris Leaves on Mild Knee Osteoarthritis
Lead Sponsor:
Pusan National University Hospital
Conditions:
Osteoarthritis
Articular Cartilage
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
Osteoarthritis (OA) is a common degenerative joint disorder that causes pain, stiffness, and functional impairment. Current treatments for OA are limited to symptom relief and have potential side effe...
Detailed Description
Osteoarthritis (OA) is a common degenerative joint disorder that causes pain, stiffness, and functional impairment. Current treatments for OA are limited to symptom relief and have potential side effe...
Eligibility Criteria
Inclusion
- Adults aged 40 to 75 years, regardless of gender
- Individuals with a Visual Analogue Scale (VAS) score of 3/10 or higher
- Individuals with a Kellgren \& Lawrence grading scale of grade 1 or 2, determined by 'Both Knee Joint AP/LAT' radiographs
- Individuals who have had a washout period of at least 4 weeks for arthritis- related medications or health supplements
- Individuals capable of normal physical activity who have voluntarily provided written informed consent to participate in this study
Exclusion
- Individuals with a history of fractures within the past year
- Individuals with osteophytes around the joints, irregular joint surfaces, or subchondral bone cysts, indicating moderate arthritis
- Individuals currently undergoing treatment for a diagnosed thyroid disorder
- Individuals with kidney disease or serum creatinine levels of 1.4 mg/dL or higher
- Individuals with proteinuria of 2+ or higher
- Individuals with liver disease or AST or ALT levels of 100 IU/L or higher
- Individuals with uncontrolled hypertension or heart conditions such as angina or myocardial infarction
- Individuals taking medication for psychiatric disorders, except for intermittent medication for sleep disorders
- Individuals who have taken herbal or medicinal decoctions within the past two months
- Individuals who have received other investigational drugs within the past four weeks
- Individuals who need to continuously take medication that may affect the outcome of the study
- Individuals with a history of gastrointestinal resection surgery (excluding appendectomy)
- Pregnant or breastfeeding women
- Individuals with alcoholism or those who drink more than four times per week regularly
- Individuals with hypersensitivity to the test food or its ingredients
- Individuals who may be uncooperative or deemed incapable of completing the study by the investigator
- Individuals with arthritis due to specific factors other than degeneration, as determined by the principal investigator
Key Trial Info
Start Date :
June 24 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06535204
Start Date
June 24 2019
End Date
April 30 2020
Last Update
August 2 2024
Active Locations (1)
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1
Pusan National University Hospital
Busan, Seo-gu, South Korea, 49241