Status:
RECRUITING
Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients
Lead Sponsor:
Helwan University
Conditions:
Acute Decompensated Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The goal of this clinical trial is to compare the effectiveness of acetazolamide versus dapagliflozin as an add-on in treating acute decompensated heart failure (ADHF) in adult patients with clinical ...
Detailed Description
A. Study design * Prospective, open-label, randomized, two-armed parallel comparator study. * Participants recruited in the study must provide written informed consent after obtaining ethical approva...
Eligibility Criteria
Inclusion
- Male or female patients of 18 years of age or older.
- An elective or emergency hospital admission with clinical diagnosis of decompensated HF with at least one clinical sign of volume overload (e.g. edema, ascites confirmed by echography or pleural effusion confirmed by chest X-ray or echography).
- Assessed LVEF by any imaging technique; i.e. echocardiography, catheterization, nuclear scan magnetic resonance imaging within 12 months of inclusion.
Exclusion
- The receipt of acetazolamide maintenance therapy.
- Receipt of an SGLT2 inhibitor in the 48 hours before randomization.
- An estimated glomerular filtration rate (eGFR) \<20 mL/min/1.73 m2.
- Use of any non-protocol defined diuretic agent with the exception of mineralocorticoid receptor antagonists during the treatment phase of the study. Thiazides, metolazone, indapamide and amiloride should be stopped upon study inclusion. If patient is taking a combination drug including a thiazide-type diuretic, the thiazide-type diuretic should be stopped.
Key Trial Info
Start Date :
August 24 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06535529
Start Date
August 24 2024
End Date
September 1 2025
Last Update
August 5 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Critical Care Medicine Department - Cairo University Hospitals.
Cairo, Egypt