Status:
RECRUITING
Functional Analysis of Salivary Glands and Correlation With Sialoscintigraphy in Sjogren's Syndrome
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Sjogren's Syndrome
Eligibility:
All Genders
20-70 years
Phase:
NA
Brief Summary
Sjögren's syndrome is a complex autoimmune disorder. The investigators hypothesize that striated ductal cells may function as non-professional antigen-presenting cells in Sjögren's syndrome. However, ...
Detailed Description
Sjögren's syndrome is a complex autoimmune disorder characterized by CD4 T lymphocyte infiltration into the salivary glands, leading to impaired glandular function. The mechanisms underlying lymphocyt...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Nomogram: no sicca symptoms
- Sicca: already receiving sialoscintigraphy
- Exclusion Criteria (generally):
- pregnancy
- breast feeding
- HIV
- cancer with active treatment
- (for nomogram)
- chronic illness needed regular follow-up
- Use anti-histamine, diuretics, anti-depressants, psychotropic medications, anxiolytics or NSAIDs that interfering saliva secretion
- smoking in recent one year
- Positive profiles for anti-SSA or anti-ENA
Exclusion
Key Trial Info
Start Date :
September 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06536075
Start Date
September 1 2023
End Date
August 1 2025
Last Update
August 6 2024
Active Locations (1)
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1
National Taiwan University Hospital
Taipei, Taiwan, 100