Status:
RECRUITING
Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects
Lead Sponsor:
Mayo Clinic
Conditions:
Chronic Lymphocytic Leukemia
Monoclonal B-Cell Lymphocytosis
Eligibility:
All Genders
40+ years
Brief Summary
This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.
Detailed Description
PRIMARY OBJECTIVES: I. Determine the cellular and mechanistic basis of bone marrow (BM) hematopoietic dysfunction in untreated MBL and CLL patients. II. Determine if MBL and CLL B cell derived cellu...
Eligibility Criteria
Inclusion
- Subjects in the CLL cohort who are eligible for these studies will have a clinically established diagnosis of CLL as assessed by flow cytometry and will include subjects who
- Remain untreated
- Are currently being treated
- Who have already been treated
- Subjects in the MBL cohort will have a clinically established diagnosis of MBL
- Healthy age-matched control subjects
- Healthy younger control subjects aged \> 40 years
Exclusion
- Anyone under 40
- Healthy control subjects must not have a diagnosis of CLL or MBL
Key Trial Info
Start Date :
November 18 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 18 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06536452
Start Date
November 18 2016
End Date
November 18 2026
Last Update
March 6 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905