Status:
NOT_YET_RECRUITING
Effects of Exosome Adminstration in Preventing Early Leakage in Rectal Cancer Patients Undergoing Low Anterior Resection
Lead Sponsor:
Tehran University of Medical Sciences
Conditions:
Rectal Cancer
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
Brief Summary
The goal of this clinical trial is to assess the safety and efficacy of Human Placenta Mesenchymal Stem Cells Derived Exosomes in preventing early anastomosis leak in patients undergoing low anterior ...
Detailed Description
Anastomotic leakage remains one of the most severe complications following colorectal surgery, leading to increased morbidity, prolonged hospitalization, and reduced quality of life. Despite advances ...
Eligibility Criteria
Inclusion
- Patients with Stage II-III rectal cancer who underwent neoadjuvant chemoradiation therapy and are candidates for low anterior resection surgery
Exclusion
- Patients who need emergency surgery (presenting with peritonitis or signs of obstruction)
- Patients with apparent malnutrition or patients who have serum albumin levels of less than 3 g/dl
- Patients who receive corticosteroids ( an equivalent dose of prednisolone 5 mg/day or more)
- Patients with chronic pulmonary disease
- Patients who need more than two units of blood transfusion perioperatively
Key Trial Info
Start Date :
August 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06536712
Start Date
August 1 2024
End Date
December 1 2024
Last Update
August 5 2024
Active Locations (1)
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1
Division of Colorectal Surgery, Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
Tehran, Iran, 1419733141