Status:
RECRUITING
Observation of Clinical Consistency of Organoid-chips Drug Sensitivity in Chemotherapy for PCa With Visceral Metastasis
Lead Sponsor:
Tianjin Medical University Second Hospital
Conditions:
Prostate Cancer
Organoid
Eligibility:
MALE
18+ years
Brief Summary
This project plans to establish an organoid chip model of prostate cancer patients with internal organ metastasis from surgical or biopsy tissue sources, and test the sensitivity of commonly used chem...
Detailed Description
This project plans to establish an organoid chip model of prostate cancer patients with internal organ metastasis from surgical or biopsy tissue sources, and test the sensitivity of commonly used chem...
Eligibility Criteria
Inclusion
- Patients with visceral metastasis of prostate cancer diagnosed clinically or pathologically;
- Age ≥ 18 years old;
- ECOG score ≤ 2 points or ECOG score 3-4 points due to tumor progression;
- Normal liver and kidney function, serum transaminase ALT\<66 U/L, AST\<36 U/L, total bilirubin\<22 umol/L, creatinine\<106 umol/L, urea nitrogen\<6.1 mmol/L; Normal bone marrow function: neutrophil count ≥ 1800/mm3 and platelet count ≥ 100000/mm3;
- Can obtain surgical or biopsy samples;
- Patients voluntarily join this study and sign an informed consent form.
Exclusion
- Patients with severe heart, liver, kidney, and peripheral nervous system diseases, as well as autoimmune diseases such as hyperthyroidism and hypothyroidism; Systemic lupus erythematosus, etc;
- Patients who are unable to obtain tissue samples;
- Subjects with active pulmonary tuberculosis (TB);
- Subjects who are preparing for or have previously undergone tissue/organ transplantation;
- Exclusion criteria are not listed, but the researchers believe that patients who are not suitable to participate in this clinical study.
Key Trial Info
Start Date :
June 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT06536725
Start Date
June 1 2024
End Date
December 31 2025
Last Update
August 5 2024
Active Locations (2)
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1
Tianjin Medical Unversity Second Hospital
Tianjin, Tianjin Municipality, China, 300211
2
Tianjin Medical Unversity Second Hospital
Tianjin, Tianjin Municipality, China