Status:
ACTIVE_NOT_RECRUITING
A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid Tumors
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Cancer-Neoplasms
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary clinical activity of RO7567132 as single agent and in combination with atezolizumab. T...
Eligibility Criteria
Inclusion
- Male or female participants aged ≥18 years
- Body weight \> 40 kilograms (kg)
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 and Life expectancy of at least 12 weeks
- Participants with advanced and/or metastatic solid tumors
- Availability and willingness to provide a mandatory archival tumor specimen or (if not available) a fresh baseline biopsy
- Negative serum pregnancy test
- Participants must have adequate cardiovascular, hematological, liver and renal function.
Exclusion
- Known central nervous system (CNS) tumors or metastases and leptomeningeal metastases
- Active second malignancy within 2 years prior to screening
- History or current clinically significant cardiovascular/cerebrovascular disease
- Active or history of autoimmune disease
- Serious, uncontrolled infection
- Known clinically significant liver disease
- Unresolved acute toxicity \> grade 1 from prior therapy
Key Trial Info
Start Date :
September 16 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 19 2029
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT06537310
Start Date
September 16 2024
End Date
June 19 2029
Last Update
December 18 2025
Active Locations (11)
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1
Kinghorn Cancer Centre
Darlinghurst, New South Wales, Australia, 2010
2
Austin Health
Heidelberg, Victoria, Australia, 3084
3
UZ Leuven Gasthuisberg
Leuven, Belgium, 3000
4
BC Cancer ? Vancouver
Vancouver, British Columbia, Canada, V5Z 4E6