Status:
TERMINATED
Metabolic Adaptations to High-fat Diet
Lead Sponsor:
George Washington University
Conditions:
Adiposity
Insulin Sensitivity
Eligibility:
All Genders
20-45 years
Phase:
NA
Brief Summary
The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood. The primary question this study seeks to address is what is the effect ...
Eligibility Criteria
Inclusion
- Males or Females between the ages of 20 and 45 years
- Body mass index (BMI) of 18.5-29.9 kg/m2
- Low risk for medical complications as determined by physical activity readiness questionnaire (PARQ).
- Low risk for food insecurity via the Hunger Vital Sign screener
Exclusion
- Currently taking any antioxidant supplementation, prescription non-steroidal anti- inflammatory drugs, antibiotics, steroids, probiotics, medications for management of cholesterol, diabetes, body weight/obesity, or are undergoing transgender hormone therapy.
- Currently pregnant (verified by urine pregnancy test)
- Any history of disordered eating (i.e., anorexia nervosa, bulimia nervosa, binge eating disorder, etc.) or high risk for disordered eating via validated questionnaire (SCOFF)
- Any history of gastrointestinal diseases (i.e., gastroesophageal reflux disease, irritable bowel syndrome, Celiac disease, Crohn's disease, or lactose intolerance)
- Allergies to wheat or gluten, milk, soy, tree nuts (e.g., almonds, walnuts, pecans), or peanuts.
- Followed a ketogenic diet within the last three months
- Instructed by a medical provided to avoid a high-fat diet due to cardiovascular disease risk.
- Cardiorespiratory fitness (VO2max) greater than the 90th percentile for age and sex
Key Trial Info
Start Date :
August 12 2024
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2024
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT06537401
Start Date
August 12 2024
End Date
December 31 2024
Last Update
August 26 2025
Active Locations (1)
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1
George Washington University School of Public Health
Washington D.C., District of Columbia, United States, 20052