Status:
NOT_YET_RECRUITING
Prediction Augmented Screening Initiative
Lead Sponsor:
VA Office of Research and Development
Conditions:
Lung Cancer
Lung Cancer Screening
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Lung cancer is responsible for more deaths in the United States than breast, prostate and colon cancer combined and is the number one cancer killer of Veterans. This is because lung cancer is usually ...
Detailed Description
Background: Despite large-randomized trials demonstrating the mortality benefit from lung cancer screening (LCS) and a recommendation from the US Preventive Services Task Force (USPSTF) and VHA since ...
Eligibility Criteria
Inclusion
- Veterans assigned a PCP at a participating site and who meet inclusion criteria at any point during the study timeframe will be enrolled into the trial. There will be two paths to patient inclusion:
- meeting USPSTF eligibility criteria for LCS, as currently encoded in the background logic of LCS clinical reminders maintained by the VA National Center for Lung Cancer Screening (i.e., age 50-80 years; smoked 20 pack-years; current smoking or quit \<15 years ago) OR
- predicted benefit calculated using LYFS-CTVA model exceeds a stringent high-benefit threshold of life-year gains with annual LCS, as recommended in the 2021 CHEST LCS guidelines
Exclusion
- Veterans who have previously undergone lung cancer screening, are diagnosed with lung cancer, or who do not meet eligibility criteria outlined above
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2029
Estimated Enrollment :
23520 Patients enrolled
Trial Details
Trial ID
NCT06538636
Start Date
January 1 2026
End Date
September 30 2029
Last Update
October 22 2025
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
VA Bedford HealthCare System, Bedford, MA
Bedford, Massachusetts, United States, 01730-1114
2
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States, 02130-4817
3
VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, Michigan, United States, 48105-2303
4
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, United States, 29401-5703