Status:
RECRUITING
DZD8586 in Patients With Relapsed or Refractory CLL/SLL (TAI-SHAN8)
Lead Sponsor:
Dizal Pharmaceuticals
Conditions:
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will treat patients with CLL/SLL whose disease comes back or is not responding to prior therapy, or if they can not bear side effects of the prior treatment. This study will assess the anti...
Eligibility Criteria
Inclusion
- Participants who meet all the following criteria:
- Male and female ≥ 18 years of age.
- ECOG performance status 0-2.
- Confirmed diagnosis of CLL/SLL with indication for treatment.
- Adequate bone marrow reserve and organ system functions.
- Willing to comply with contraceptive restrictions.
Exclusion
- Participants who meet any of the following criteria:
- CNS involvement or Richter transformation.
- Stem cell transplantation, cell therapy, or gene therapy within 90 days. Approved small molecule therapy within 5 half-lives, monoclonal antibodies and antibody-drug conjugates within 28 days.
- Major surgery or significant traumatic injury within 4 weeks. Live attenuated vaccines or viral vector vaccines within 4 weeks.
- Take vitamin K antagonists or take more than 2 anticoagulants or antiplatelet drugs at the same time. Take proton pump inhibitors or strong CYP3A inhibitors or inducers.
- Active infection.
- Clinically significant cardiac disorders or abnormalities. History of thrombotic diseases, stroke or intracranial hemorrhage within 6 months.
- Nausea and vomiting not controlled or chronic gastrointestinal diseases, unable to swallow the formulated product or previous bowel resection that would preclude adequate absorption.
- Another malignancy within 2 years prior to enrollment with the exception of adequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cell carcinoma or non-melanomatous skin cancer.
- Women who are breast feeding.
- History of hypersensitivity to active or inactive excipients of DZD8586 or drugs with a similar chemical structure or class.
Key Trial Info
Start Date :
April 29 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
155 Patients enrolled
Trial Details
Trial ID
NCT06539182
Start Date
April 29 2024
End Date
March 1 2028
Last Update
December 1 2025
Active Locations (17)
Enter a location and click search to find clinical trials sorted by distance.
1
Research Site
Hefei, Anhui, China
2
Research Site
Beijing, Beijing Municipality, China, 100053
3
Research Site
Beijing, Beijing Municipality, China, 100191
4
Research Site
Guangzhou, Guandong, China, 510280