Status:
RECRUITING
Clinical Study Evaluating the Effect of Losartan
Lead Sponsor:
Tanta University
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
50-85 years
Phase:
NA
Brief Summary
The pancreas is two organs packaged into one. The islets of Langerhans serve critical endocrine functions, and the exocrine portion is a major source of enzymes that are essential for digestion. Panc...
Detailed Description
Pancreatic cancer has multi step carcinogenesis, starting from Pancreatic Intra-ductal Neoplasia and ends with an invasive neoplastic lesion.Pancreatic cancer is most frequent in elder people; the ris...
Eligibility Criteria
Inclusion
- Male and female pancreatic cancer patients aged ≥ 50 years old.
- Hypertensive patient with BP ≥ 140/90 mm Hg.
- Histologically confirmed metastatic pancreatic adenocarcinoma; or locally advanced pancreatic cancer patients.
- All included patients must sign an informed consent
Exclusion
- Patients with serious concomitant systemic disorders as significant cardiac, renal, hepatic, or pulmonary morbidity.
- Pregnant or lactating women and women of childbearing potential.
- Patients received prior systemic fluoropyrimidine therapy within the past 10 years.
- Prior un-anticipated severe reaction to fluoropyrimidine therapy, or known hypersensitivity to 5-fluorouracil, irinotecan, oxaliplatin, losartan, or any monoclonal antibody.
- Patients with an active, known, or suspected autoimmune disease such as psoriasis.
- Patients with a known positive test for hepatitis B virus surface antigen (HBV s Ag) or hepatitis C virus (HCV antibody) and patients with a known history of testing positive for (HIV) or known acquired immunodeficiency syndrome (AIDS).
- Patients received a live vaccine or live attenuated vaccines as intranasal influenza vaccines within 30 days of the planned start of study therapy.
Key Trial Info
Start Date :
July 20 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 20 2026
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06539806
Start Date
July 20 2024
End Date
August 20 2026
Last Update
August 6 2024
Active Locations (1)
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1
Tanta University Hospital
Tanta, Egypt