Status:
RECRUITING
A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery
Lead Sponsor:
University of Malaya
Conditions:
Postoperative Nausea and Vomiting
Scoliosis
Eligibility:
All Genders
10+ years
Phase:
PHASE4
Brief Summary
The aim of this clinical trial is to compare the effectiveness of two Serotonin (5- HT3) receptor antagonist, palonosetron and granisetron, administered along with dexamethasone as a preventive measur...
Detailed Description
Postoperative nausea and vomiting (PONV) remains a common adverse event after surgery and anaesthesia causing much dissatisfaction among patients. PONV incidence is reported at 30% in all surgical pat...
Eligibility Criteria
Inclusion
- Age: 10 years and above
- American Society of Anesthesiologists (ASA) class I-II
Exclusion
- Active smoker
- Obesity with body mass index (BMI) of 34 and above
- Body weight of less than 30kg
- History of gastro-esophageal reflux disease (GERD)/ other gastrointestinal diseases associated with vomiting
- History of motion sickness
- History of allergy to 5-HT3 (serotonin) receptor antagonists or dexamethasone
- History of nausea or vomiting withing 24 hours before surgery
- History of administration of antiemetics/ steroids/ psychoactive medications within 24 hours before the surgery
- History of cardiac arrhythmias
- Prolonged QT (QTc is prolonged if \> 430ms in men or \>450ms in women)
Key Trial Info
Start Date :
January 6 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT06540885
Start Date
January 6 2025
End Date
September 30 2026
Last Update
April 25 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
University Malaya
Pantai Valley, Kuala Lumpur, Malaysia, 59100
2
University Malaya Medical Centre
Kuala Lumpur, Malaysia, 50603