Status:
COMPLETED
Investigation of LBX1, TIMP2, GPR126 and CHD7 Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients
Lead Sponsor:
Uludag University
Conditions:
Adolescent Idiopathic Scoliosis
Single Nucleotide Polymorphisms
Eligibility:
All Genders
10-18 years
Brief Summary
Adolescent Idiopathic Scoliosis (AIS) is a common disease of the spine observed in individuals aged 10-18 who typically do not have any other health issues. Despite numerous genetic studies conducted ...
Detailed Description
This prospective genetic research was conducted Bursa Uludag University Faculty of Medicine, Department of Orthopedics and Traumatology. A total of 301 individuals were included in the study, comprisi...
Eligibility Criteria
Inclusion
- Study group
- Being diagnosed with Adolescent Idiopathic Scoliosis (AIS) between the ages of 10 and 18.
- Having a Cobb angle of 10 degrees or greater on a plain radiograph.
- Not having any known genetic disorders.
- Not having any diseases known to play a role in the etiology of scoliosis (degenerative, neuromuscular, congenital scoliosis, etc., are excluded).
- Control group
- Healthy individuals who have not been diagnosed with scoliosis by physical examination and/or imaging.
- Being between the ages of 10-18
Exclusion
- Study group
- Those diagnosed with non-idiopathic scoliosis.
- Individuals who develop scoliosis after the age of 18.
- Individuals with scoliosis under the age of 10.
- Those diagnosed with a genetic disease.
- Those diagnosed with any disease known to play a role in the etiology of scoliosis.
- Control group
- Those who have physical examination suspicion of scoliosis.
- Those with a Cobb angle of 10 degrees or more on plain radiographs.
Key Trial Info
Start Date :
July 8 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 8 2023
Estimated Enrollment :
301 Patients enrolled
Trial Details
Trial ID
NCT06540924
Start Date
July 8 2022
End Date
July 8 2023
Last Update
August 9 2024
Active Locations (1)
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1
Uludag University
Bursa, Turkey (Türkiye), 16059